UC Davis School of Veterinary Medicine Veterinary Genetics Laboratory
Canine Genetic Heritage Projects
Understanding the biology of the domestic dog
Updated Data for the MDR1 Project .

This table lists the percentages of dogs that are affected by the mutation in each breed


Affected dogs in breed populations with MDR1-1
Breed
No. of Dogs
Tested
Super
Sensitive
Sensitive Normal
Australian Shepherd
179
2%
30%
68%
Australian Shepherd, Miniature 56 4%
45%
52%
Collie 287
32%
46%
22%
English Shepherd 91
<1%
14%
86%
McNab 35
3%
29%
69%
Old English Sheepdog 212
1%
9%
90%
Shetland Sheepdog 214
2%
17%
80%
Silken Windhound 124
1%
37%
62%
Longhaired Whippet 89
16%
52%
33%



Super-Sensitive = 2 defective copies
Sensitive = 1 defective copy
Normal = 0 defective copies



The breeds below do not appear to be affected by the mutation. It remains formally possible, however, that the mutation is present, but at a low frequency


Breeds seemingly unaffected by MDR1-1
Breed No. of Dogs
Tested
Australian Cattle Dog
105
Australian Kelpie
109
Bearded Collie
136
Belgian Malinois
63
Belgian Tervuren
104
Bernese Mountain Dog
111
Border Collie
222
Borzoi
91
English Setter
73
Flat Coated Retriever
111
Greyhound
110
Italian Greyhound
117
Jack Russell Terrier
91
Koolie
56
Labrador Retriever
113
Pembroke Welsh Corgi
132
Whippet
105



Note: There have been recent reports on the internet that the mutation has been found in Border Collies.


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Veterinary Genetics Laboratory, Tel 530-752-2211, Email VGL