UC Davis School of Veterinary Medicine Veterinary Genetics Laboratory
Dr. Niels C. Pedersen
Genetic Research Projects of Dr. Niels C. Pedersen

Feline

Dr. Pedersen has also maintained a significant research program into the genetics of cats.  His primary interest has involved in identifying potential genetic associations with resistance to a highly fatal and common infectious disease of cats, feline infectious peritonitis (FIP).   This resistance involves both genetic factors involved with host immunity, as well as viral genetic factors that influence virus/host interactions. 

Watanabe R, Eckstrand C, Liu H, Pedersen NC. Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seq. Vet Res. 2018, 49, 81. doi: 10.1186/s13567-018-0578-y.

Pedersen NC, Kim Y, Liu H, Galasiti Kankanamalage AC, Eckstrand C, Groutas WC, Bannasch M, Meadows JM, Chang KO. Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis. J Feline Med Surg. 2018, 20, 378-392.

Murphy BG, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, Liepnieks M, Pedersen NC. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 2018, 219, 226-233.

Kim Y, Liu H, Galasiti Kankanamalage AC, Weerasekara S, Hua DH, Groutas WC, Chang KO, Pedersen NC. Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor. PLoS Pathog. 2016, 12, doi: 10.1371/journal.ppat.1005531.

Pedersen NC, Liu H, Durden M, Lyons LA. Natural resistance to experimental
feline infectious peritonitis virus infection is decreased rather than increased by positive genetic selection. Vet Immunol Immunopathol. 2016 Mar;171:17-20. http://www.sciencedirect.com/science/article/pii/S0165242716300022.

Pedersen NC, Eckstrand C, Liu H, Leutenegger C, Murphy B. Levels of feline infectious peritonitis virus in blood, effusions, and various tissues and the role of lymphopenia in disease outcome following experimental infection. Vet Microbiol. 2015, 175, 157-166.

Pedersen NC, Liu H, Gandolfi B, Lyons LA. The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis. VetImmunol Immunopathol. 2014 Nov 15;162(1-2):33-40. http://www.sciencedirect.com/science/article/pii/S0165242714001998.

Golovko L, Lyons LA, Liu H, Sørensen A, Wehnert S, Pedersen NC. Genetic susceptibility to feline infectious peritonitis in Birman cats. Virus Res. 2013, 175, 58-63.

Pedersen NC, Liu H, Scarlett J, Leutenegger CM, Golovko L, Kennedy H, Kamal FM. Feline infectious peritonitis: role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats. Virus Res. 2012, 165, 17-28.

Pedersen NC, Liu H, Dodd KA, Pesavento PA. Significance of coronavirus mutants in feces and diseased tissues of cats suffering from feline infectious peritonitis. Viruses. 2009, 1, 166-84.

Vennema H, Poland A, Foley J, Pedersen NC. Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses. Virology. 1998, 243, 150-7.

Poland AM, Vennema H, Foley JE, Pedersen NC. Two related strains of feline infectious peritonitis virus isolated from immunocompromised cats infected with a feline enteric coronavirus. J Clin Microbiol. 1996, 34, 3180-4.

Pedersen NC. Virologic and immunologic aspects of feline infectious peritonitis virus infection. Adv Exp Med Biol. 1987;218, 529-50.

In addition to genetic research into FIP, Dr. Pedersen has collaborated on several other studies involving genetic diversity of domestic cats as well as simple genetic diseases.

Jones BR, Little S, Lyons LA, Malik R, Nicholas F, O'Brien DP, Pedersen NC. Understanding genetics: why should vets care? J Feline Med Surg. 2015, 17,201-2

Alhaddad H, Gandolfi B, Grahn RA, Rah HC, Peterson CB, Maggs DJ, Good KL, Pedersen NC, Lyons LA. Genome-wide association and linkage analyses localize a progressive retinal atrophy locus in Persian cats. Mamm Genome. 2014 Aug; 25(7-8), 354-62. http://link.springer.com/article/10.1007/s00335-014-9517-z

Lipinski MJ, Froenicke L, Baysac KC, Billings NC, Leutenegger CM, Levy AM, Longeri M, Niini T, Ozpinar H, Slater MR, Pedersen NC, Lyons LA. The ascent of cat breeds: genetic evaluations of breeds and worldwide random-bred populations.  Genomics. 2008, 91, 12-21.

 
Veterinary Genetics Laboratory, Tel 530-752-2211, Email VGL