UC Davis School of Veterinary Medicine Veterinary Genetics Laboratory

Osteochondrodysplasia (OCD) in Miniature Poodles

Introduction

Osteochondrodysplasia (OCD) is an inherited disorder found in Miniature Poodles. The disease is characterized by stunted growth and abnormal locomotion that can be observed at about 3 weeks of age. Affected animals develop abducted (splayed) hind limbs, enlarged joints, flattened rib cages, shortened and bent long bones and deformed paws. The inheritance is autosomal recessive, thus both sexes are equally affected and carriers show no signs of the disease. Research has identified a deletion in the Sulfate Transporter gene, SLC13A1, which is associated with OCD in Miniature Poodles.

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Results reported as:

N/N Normal - no copies of OCD deletion are present.
N/OCD

Carrier - 1 copy of OCD deletion is present. If carriers are bred together, 25% of offspring are expected to be affected.

OCD/OCD Affected - 2 copies of OCD deletion are present.

Reference:

Neff MW, Beck JS, Koeman JM, Boguslawski E, Kefene L, Borgman A, Ruhe AL. (2012) Partial deletion of the Sulfate Transporter SLC13A1 is associated with an osteochondrodysplasia in the Miniature Poodle breed. PLoS ONE 7(12): e51917. Doi:10.1371/journal.pone.0051917

 
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