UC Davis School of Veterinary Medicine Veterinary Genetics Laboratory

Exercise-Induced Collapse

Exercise-Induced Collapse (EIC) is a genetic neuromuscular disorder characterized by muscle weakness, lack of coordination and life-threatening collapse after intense exercise in otherwise apparent healthy dogs. Affected dogs tolerate mild to moderate activity but will display signs of EIC after 5-20 minutes of strenuous exercise. The severity of EIC varies, some affected dogs continue to run while dragging their hind legs while others have progression of weakness from rear to forelimbs resulting in a total inability to move. EIC events are often accompanied by a dramatic elevation of body temperature, although unaffected dogs also exhibit elevated temperatures under the same exercise conditions. EIC episodes last from 5-25 minutes with a gradual return to normal with no apparent residual weakness or stiffness. Affected dogs show signs of the disorder as early as 5 months of age, which is typically when more strenuous training and activity begins. Dogs with EIC can lead full, productive lives with proper management.  Owners of affected dogs should familiarize themselves with the types of activities that are appropriate for their dogs as well as specific triggers of EIC episodes.

EIC is caused by a mutation in dynamin 1 gene (DNM1 c.767G>T). It is inherited as an autosomal recessive disorder, which means that both males and females are affected equally, and that two copies of the mutation are needed to cause the disease. Dogs with one copy of the normal gene and one copy of the mutation (carriers) do not exhibit any signs of EIC.

The Veterinary Genetics Laboratory offers a genetic test for EIC. Test results assist veterinarians with diagnosis of EIC and help breeders identify carriers among breeding stock to avoid producing affected dogs. Matings between carriers are expected to produce 25% of affected puppies.

Testing recommendation:  Australian Cobberdog, Australian Labradoodle, Bouvier des Flandres, Boykin Spaniel, Cardigan Welsh Corgi, Chesapeake Bay Retriever, Cockapoo, Cocker Spaniel, Clumber Spaniels, Curly Coated Retriever, Deutsch-Drahthaar, English Cocker Spaniel, German Wirehaired Pointer, Labrador crosses, Labradoodle, Labrador Retriever, Old English Sheepdog, Pembroke Welsh Corgi, Vizsla

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Allow 5-10 business days for results.

Results reported as:

N/N

No copies of the EIC mutation.

N/EIC

1 - copy of the EIC mutation. Dog is a carrier. If bred to an N/N dog, 50% of offspring are predicted to be EIC carriers.

EIC/EIC

2 - copies of the EIC mutation. Dog is affected and, if induced, may exhibit exercise-induced collapse. If bred, dog will pass on a copy of EIC to all offspring.

References:

Patterson EE, Minor KM, Tchernatynskaia AV, Taylor SM, Shelton GD, Ekenstedt KJ, Mickelson JR. (2008). A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse. Nat Genet. 40(10):1235-1239.

Minor KM, Patterson EE, Keating MK, Gross SD, Ekenstedt KJ, Taylor SM, Mickelson JR. (2011). Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds. Vet J. 189(2):214-219.

 
Veterinary Genetics Laboratory, Tel 530-752-2211, Email VGL