UC Davis School of Veterinary Medicine Veterinary Genetics Laboratory

Genetic Diversity Testing

(Phase 1 - Research)

Overview

The Veterinary Genetics Laboratory (VGL), in collaboration with Dr. Niels C. Pedersen and staff, has developed a panel of short tandem repeat (STR) markers that will determine genetic diversity across the genome and in the Dog Leukocyte Antigen (DLA) class I and II regions. This test panel will be useful to breeders who wish to track and increase genetic diversity of their breed as a long term goal.

Genetic testing is now in the development phase -please see Enrolling a Breed. During this phase, we need to test 100 or more dogs to provide baseline genetic data necessary to provide breeders with an accurate preliminary assessment of genetic diversity in their breed. We encourage breeders to submit samples from active dogs to further build the database. The goal is to test enough dogs so that no new alleles or DLA haplotypes are recognized.

Price: $50. This is the cost for the dogs that will be tested in the research phase. Once the research phase is complete, the test will be offered at the regular rate of $80.

ORDER TEST KITS
Results will be reported when sufficient data has been compiled.

Results reported as:
Short tandem repeat (STR) loci: A total of 33 STR loci from across the genome were used to gauge genetic diversity within an individual and across the breed. The alleles inherited from each parent are displayed graphically to highlight heterozygosity, and breed-wide allele frequency is provided.

DLA haplotypes: STR loci linked to the DLA class I and II genes were used to identify genetic differences in regions regulating immune responses and self/non-self recognition. Problems with self/non-self recognition, along with non-genetic factors in the environment, are responsible for autoimmune disease.

Internal Relatedness: The IR value is a measure of genetic diversity within an individual that takes into consideration both heterozygosity of alleles at each STR loci and their relative frequency in the population. Therefore, IR values heterozygosity over homozygosity and uncommon alleles over common alleles. IR values are unique to each dog and cannot be compared between dogs. Two dogs may have identical IR values but with very different genetic makeups.

Veterinary Genetics Laboratory, Tel 530-752-2211, Email VGL