UC Davis School of Veterinary Medicine Veterinary Genetics Laboratory
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Autosomal Recessive Amelogenesis Imperfecta(ARAI) or Familial Enamel Hypoplasia of Italian Greyhounds

Introduction

Autosomal recessive amelogenesis imperfecta (ARAI) is an inherited genetic disorder of tooth enamel that occurs in Italian Greyhounds. It is commonly known to breeders as Familial Enamel Hypoplasia (FEH). It is characterized by enamel pitting and tooth discoloration; often teeth are unusually small, pointed and prone to increasing gaps between teeth with age. There appears to be no association of FEH with periodontitis. Dr. Niels Pedersen and his research group at the School of Veterinary Medicine, University of California-Davis identified the mutation associated with FEH in Italian Greyhounds.  It is estimated that 14% of Italian Greyhounds are affected with FEH and 30% are carriers.

Italian Greyhound with normal teeth. Teeth are larger, not pointed; enamel is smooth, not discolored. Gaps between teeth are narrower.

Italian Greyhound with FEH. The enamel surfaces are roughened, with blochy discoloration. Cavities are uncommon, but this dog has cavities at tips of upper and lower canines.

The Veterinary Genetics Laboratory offers a test for FEH to assist owners and breeders in identifying affected and carrier dogs. The test uses DNA collected from buccal (cheek) swabs, thus avoiding blood sample collection. Breeders can use results from the test as a tool for selection of mating pairs to avoid producing affected dogs.

Female

Male

N/N

N/FEH

FEH/FEH

N/N

100% N/N

50% N/N, 50% N/FEH

100% N/FEH

N/FEH

50% N/N, 50% N/FEH

25% N/N, 50% N/FEH, 25% FEH/FEH

50% N/FEH, 50% FEH/FEH

FEH/FEH

100% N/FEH

50% N/FEH, 50%FEH/FEH

100%FEH/FEH

ORDER TEST KITS | PRICE LIST
Allow 2-6 business days for results.

Results reported as:

N/N: no copies of FEH mutation; dog is normal
N/FEH: 1 copy of FEH mutation; dog is normal but is a carrier
FEH/FEH: 2 copies of FEH mutation; dog is affected.

 

 
Veterinary Genetics Laboratory, Tel 530-752-2211, Email VGL