UC Davis School of Veterinary Medicine Veterinary Genetics Laboratory
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Red Factor

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The Extension gene (red factor) has two alternative states (alleles). The dominant allele E produces black pigment in the coat. The recessive allele e produces red pigment. Red horses (chestnuts, sorrels, palominos and red duns, to name a few) are homozygous, that is they have two alleles, for the recessive red allele ee. Black pigmented horses (black, bay, brown, buckskin and grullo, to name a few) have at least one E allele. They can be homozygous EE or heterozygous Ee. A horse that is homozygous EE will not produce red offspring, regardless of the color of the mate.

The DNA diagnostic test for red factor can be used to identify those black horses for which neither pedigree nor breeding records is informative for identifying carriers of the recessive red factor. Since red is inherited as a recessive trait, it is relatively easy to start up a breeding program that will produce only red horses. It has been more difficult to initiate a black breeding program as black Ee horses can produce red foals. Prior to the development of this test, only pedigree or breeding records, not phenotype, could provide information about whether black horses are EE or Ee.

Red Factor results are reported as:

e/e Only red factor detected. Basic color is red in the absence of modifying genes.
E/e Both black and red factors detected.
E/E No red factor detected. Offspring cannot be chestnut/sorrel.
 
Veterinary Genetics Laboratory, Tel 530-752-2211, Email VGL